Kidney Failure

Kidney failure, also known as end-stage kidney disease (ESKD), is the final stage of chronic kidney disease (CKD). At this point, the kidneys can no longer perform their essential functions, such as filtering waste products and excess fluid from the blood, regulating blood pressure, and maintaining electrolyte balance.

In stage 5 CKD, about 85-90% of kidney function is lost. People with kidney failure typically require either dialysis or a kidney transplant to stay alive.

Dialysis: This is a medical procedure that takes over some of the kidney’s functions. There are two main types of dialysis: hemodialysis, where a machine filters waste from the blood, and peritoneal dialysis, which uses the lining of the abdomen to filter the blood.
Kidney transplant: A transplant involves receiving a healthy kidney from a donor, which can potentially restore normal kidney function. However, not everyone is a candidate for a transplant, and there can be long waiting times for available donor kidneys.

About Kidney Failure

Kidney disease often progresses silently, especially in its early stages. The kidneys have a remarkable ability to compensate for damage, so people may not experience noticeable symptoms until the condition has reached a more advanced stage. This is why it’s important to monitor kidney function regularly, especially for individuals at higher risk, such as those with diabetes, high blood pressure, or a family history of kidney disease. Early detection through blood and urine tests can help slow down the progression of kidney disease and prevent kidney failure.

Signs and symptoms

  • Urinating (peeing) less often than usual or not at all
  • Trouble concentrating
  • Shortness of breath
  • Itchy and/or dry skin
  • Achy muscles or cramping
  • Nausea and/or vomiting
  • Loss of appetite
  • Feeling tired
  • Numbness or swelling in your arms, legs, ankles, or feet
  • Trouble sleeping

Causes/Risk factors

  • Diabetes and high blood pressure are the leading causes of kidney failure, contributing to about two-thirds of the cases. Both conditions can damage the blood vessels in the kidneys over time, impairing their ability to filter waste and excess fluids.
  • Other conditions like IgA nephropathy, where an antibody builds up in the kidneys, and lupus nephritis, which is inflammation caused by lupus, can also lead to kidney damage. Polycystic kidney disease, where cysts form in the kidneys, and Fabry disease, a genetic condition, are additional causes of kidney problems.
  • Social and environmental factors, such as smoking, poor diet, lack of physical activity, and exposure to toxins, can further increase the risk of kidney disease. For instance, certain medications, obesity, and even chronic dehydration can harm kidney function over time.

Complications

Kidney failure can indeed lead to a range of serious health complications, and managing these requires careful monitoring and treatment. Each of the conditions you mentioned can significantly affect the body and interact with kidney failure in different ways:

  • Anemia: When the kidneys fail, they produce less erythropoietin, a hormone that helps the bone marrow make red blood cells. This can lead to anemia, causing fatigue, weakness, and shortness of breath.
  • Metabolic Acidosis: The kidneys are responsible for maintaining the body’s pH balance. When they fail, the body can accumulate excess acid, leading to metabolic acidosis. This can cause symptoms like rapid breathing, confusion, and lethargy.
  • Mineral and Bone Disorder: Kidneys help regulate levels of calcium and phosphate in the blood, and kidney failure disrupts this balance. This can lead to weak bones (osteoporosis) and increase the risk of cardiovascular disease. It can also cause calcification in blood vessels and organs, leading to further complications.
  • Hyperkalemia: High potassium levels in the blood can be dangerous, potentially causing abnormal heart rhythms (arrhythmias) or even cardiac arrest. Kidney failure impairs the body’s ability to filter out excess potassium, making this a serious concern.

Treatments

There is no cure for kidney failure, but with treatment it is possible to live a longer and productive life.

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